Saos-2 is a cell line with epithelial morphology that was isolated from the bone of an 11-year-old, White, female osteosarcoma patient treated with RTG, methotrexate, adriamycin, vincristine, cytoxan, and aramycin-C. Use this cell line as a transfection host and in your cancer research.

Saos-2 ("sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. [1] The cell line is commonly used in bone cancer research as a model for testing novel therapies.

Materials and methods: We compared three osteosarcoma cell lines (MG-63, Saos-2 and U-2 OS) with normal human osteoblasts by immunocytochemistry. Cellular characteristics were assessed by morphometric analysis and proliferation kinetics.

Saos-2 is a human osteosarcoma cell line, which displays several osteoblastic features. These cells express receptors for 1,25-dihydroxyvitamin D 3 and have high basal alkaline-phosphatase activity. They express the parathyroid hormone (PTH) receptor and produce cyclic AMP in response to treatment with PTH.

Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. p53 functions as a cell cycle control protein in osteosarcomas. Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor. Hum. Pathol. 27:408-416 (1996)

The control group (SaOS-2 cells which were incubated in Dulbecco Modified Eagle Medium without any kind of bone graft materials) had the highest level of cell viability (P<0.001), followed by Tutodent ®, Osteon ®, Cerasorb ®, and Bio-Oss ®.

During culture under the appropriate mineralising conditions, SaOS2 cells reproducibly synthesised a bone-like mineralised matrix and temporally expressed the mature osteocyte marker genes SOST, DMP1, PHEX and MEPE and down-regulated expression of …

SaOS-2 is a cell line derived from primary osteosarcoma. SaOS-2 cells behave as osteoblastlike cells and are commonly used in bone-related research [ 64 ]. Advantages of the SaOS-2 cell line include the capability to get a large number of cells in a short time, and differentiation in a similar way as osteoblasts do [ 65 ].

SAOS-2 : DSMZ no.: ACC 243: Species: human (Homo sapiens) Cell type: osteogenic sarcoma : Origin: established from the primary osteogenic sarcoma of an 11-year-old girl in 1973; cells secrete particulate matter containing bone inducing agents thought to comprise bone morphogenic proteins (BMP-1, -2, -3, and -6) Reference(s): 15135, 14538, 14537 ...

Here you can copy and paste the header of your file, e.g. Excel, and the respective values. Columns must be separated by tabs or spaces. The header must include loci and alleles, separated by an underscore. If no allele is given, it is assumed to …