5 days ago · Polyclonal Antibody for studying STAT3. Validated for ChIP, IHC, IP, WB. Highly specific and rigorously validated in-house, Stat3 Antibody (CST #9132) is ready to ship.

2 days ago · Phospho-Stat3 (Tyr705) Antibody detects endogenous levels of Stat3 only when phosphorylated at Tyr705. The antibody does not cross-react with other Stat proteins when phosphorylated on the corresponding tyrosine residue, but has been shown to cross-react with Phospho-EGFR.

STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.

STAT3 was first described as a transcriptional enhancer of acute phase genes that is activated by IL6 (interleukin 6). 7 The STAT3 gene is located on chromosome 17q21 and encodes an 89-kDa protein.

Stat3 (124H6) Mouse mAb detects endogenous levels of total Stat3 protein. Human, Mouse, Rat, Monkey. Monoclonal antibody is produced by immunizing animals with a synthetic peptide centered around amino acid Gln692 of human Stat3.

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic targets for the treatment of cancer. In particular, STAT-3 serves critical roles in several cellular processes, including the cell cycle, cell proliferation, cellular apoptosis and tumorigenesis.

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb detects endogenous levels of Stat3 only when phosphorylated at tyrosine 705. This antibody does not cross-react with phospho-EGFR or the corresponding phospho-tyrosines of other Stat proteins.