Nov 7, 2018 · Using an electrochemical approach, we reveal the precise time course of pinch-evoked dopamine release in the mPFC, and show that mPFC dopamine biases behavioural responses to aversive stimuli.

We propose a framework wherein dopamine can serve as a signal for switching mPFC states by orchestrating how information is routed to the rest of the brain. Keywords: Valence, Signal-to-noise ratio, Mesocortical, Aversion, Mesolimbic. 1. Introduction to mesocortical dopamine.

Feb 2, 2014 · We compare acquisitions at three different in-plane spatial resolutions (3.50 × 3.50 mm 2, 2.33 × 2.33 mm 2, 1.75 × 1.75 mm 2) in terms of their tSNR, contrast-to-noise ratio, and the power to detect both task-related activation and resting-state functional connectivity.

Nov 27, 2018 · Dopamine (DA) has been suggested to increase the signal-to-noise ratio (SNR) of neural activity in the medial prefrontal cortex (mPFC); however, direct evidence of this model is lacking.

Aug 24, 2023 · In contrast, the medial prefrontal cortex (mPFC) and amygdala receive relatively sparse dopaminergic innervation that regulates a wide range of brain functions important in mediating cognitive function 8,9, social interactions 10, and aversive sensing 11,12.

Nov 3, 2021 · In addition to strong projections in the VM and VA motor thalamus, SNr neurons also target the mediodorsal (MD) thalamus (McElvain et al., 2021), and the MD strongly activates the medial prefrontal cortex (mPFC) neurons (Collins et al., 2018).

In mice, mPFC L2 neurons project to the contralateral mPFC, BLA, SNR in control. However, PRSS12 overexpressing mouse mPFC L2 neurons showed decreased projection to BLA and SNR. Similarly, the marmoset A32 exhibits less projection to BLA and SNR compared to contralateral mPFC.

Recent advances in tracer paramagnetic metallo-perfluorocarbon (MPFC) nanoemulsion probes have shown multifold SNR improvements due to an accelerated 19 F T 1 relaxation rate and a commensurate gain in imaging speed and averages.

Nov 1, 2018 · Using an electrochemical approach, we reveal the precise time course of pinch-evoked dopamine release in the mPFC, and show that mPFC dopamine biases behavioural responses to aversive stimuli.

Mar 9, 2024 · By recording neural activity in the superior colliculus (SC) while phototagging specific responses to afferents, we established the crucial influence of input arriving at the SC from the medial...