Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely studied in various types of cancers. ROS are considered to be normal byproducts of numerous cellular processes. Typically, cancer cells exhibit higher basal levels of ROS compared with normal cells as a result of an imbalance between oxidants and antioxidants.

Feb 14, 2020 · Moderate increases of ROS contribute to several pathologic conditions, among which are tumor promotion and progression, as they are involved in different signaling pathways and induce DNA...

Jan 31, 2022 · ROS impact the behaviour of both cancer cells and the stromal components of the tumour to modulate cancer development and survival. In this Review, we examine the different characteristics of ROS...

Jul 9, 2024 · The effect of reactive oxygen species (ROS) on cancer cells and the immune system is concentration-dependent and can be either stimulatory or suppressive in nature.

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. ...

In this review, we not only discuss the double-edged roles and molecular regulatory mechanisms of ROS in cancer prevention and therapy, but also summarize the relevant small molecule interventions and envision the future perspectives of ROS-targeted cancer treatment.

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting transformation/proliferation of cancer cells or causing cell death.

Feb 28, 2017 · Extensive research over the past half a century indicates that reactive oxygen species (ROS) play an important role in cancer. Although low levels of ROS can be beneficial, excessive accumulation can promote cancer.

Sep 21, 2021 · Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells.

Disruption of redox homeostasis has been associated with various human diseases, especially cancer, in which increased ROS levels are thought to have a major role in tumour development and progression.