The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K ir 1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion …

The apically located renal outer medullary K + (ROMK) channel provides a pathway for K + to recycle from cell to lumen, and ensures an adequate supply of K + to sustain Na +-K +-2Cl − cotransport. This movement through ROMK creates a lumen-positive voltage, providing a driving force for passive K + reabsorption through the paracellular pathway.

Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

Oct 1, 2009 · ROMK encodes a major potassium secretory channel in the kidney. In distal nephron principal cells, ROMK1 and ROMK3 form the predominant 30-pS potassium channel. The high density and activity of these channels permit avid potassium flux into the tubular lumen.

A large body of evidence indicates that ROMK channel activity is regulated by endocytosis and exocytosis. ROMK channels have been shown to interact with clathrin via AP-2 protein .

ROMK is a gene encoding inwardly rectifying adenosine triphosphate regulated K+ channels. Alternative splicing of ROMK exons yields several different transcripts, ROMK 1-3, that are differentially expressed along the nephron.

In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors.

ROMK (Kir1.1) is a potassium channel that is primarily found on the apical surface of epithelial cells in the thick ascending limb of Henle (TALH) and cortical collecting duct (CCD) in the nephron.

Mar 30, 2009 · ROMK shares the salient biophysical features of the small- conductance potassium channels in the TAL and collecting duct apical membrane, the absence of sensitivity to cytoplas-

ROMK, or the Renal Outer Medullary Potassium channel, is a critical component in the regulation of potassium homeostasis within the kidney. It is responsible for the reabsorption and secretion of potassium ions, playing a vital role in the tubular reabsorption process.