Ribonuclease 4 - Wikipedia
Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene. [5][6] Shown is a PyMol image of the ribonuclease 4 dimer, blue, with deoxyuridine monophosphate, white, in the active site. PDB: 2RNF. The protein encoded by this …
RNASE4 Gene - GeneCards | RNAS4 Protein | RNAS4 Antibody
Mar 30, 2025 · RNASE4 (Ribonuclease A Family Member 4) is a Protein Coding gene. Diseases associated with RNASE4 include Amyotrophic Lateral Sclerosis 9 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 .
Ribonuclease 4 functions as an intestinal antimicrobial protein to ...
Jul 10, 2024 · Ribonuclease 4 (Rnase4) is a potential antimicrobial protein with no known function in the intestines. Here we find that RNASE4 is expressed in intestinal epithelial cells (IEC) including...
RNase 4 - NEB
RNase 4 is a single-stranded endoribonuclease that cleaves RNA at uridine-purine (U/R) dinucleotide sites. Endoribonuclease activity tolerates common RNA chemical modifications. Enhance analysis of mRNA 5′ cap identity and distribution.
RNASE4 ribonuclease A family member 4 [ (human)] - National …
Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis. Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer. Expression and function of human ribonuclease 4 in the kidney and urinary tract.
Ribonuclease 4 is associated with aggressiveness and progression …
Jun 25, 2022 · RNASE4 protein in prostate cancer tissues is enhanced and can differentiate prostate cancer and BPH. RNASE4 stimulates prostate cancer cell proliferation, induces tumor angiogenesis, and...
Transcription of angiogenin and ribonuclease 4 is regulated by …
May 2, 2014 · Angiogenin (ANG) and ribonuclease 4 (RNASE4), two members of the secreted and vertebrate-specific ribonuclease superfamily, play important roles in cancers and neurodegenerative diseases. The ANG and RNASE4 genes share genetic regions with promoter activities, but the structure and regulation of the …
Ribonuclease 4 protects neuron degeneration by promoting
Nov 10, 2012 · Moreover, RNASE4 not only stimulates the formation of neurofilaments from mouse embryonic cortical neurons, but also protects hypothermia-induced degeneration. Importantly, systemic treatment with RNASE4 protein slowed weight loss and enhanced neuromuscular function of SOD1 G93A mice.
RNASE4 ribonuclease A family member 4 [ Homo sapiens (human) ]
Nov 27, 2024 · Data show that the transcription of angiogenin (ANG) and ribonuclease 4 (RNASE4) promoter is influenced by RNA polymerase III (Pol III) elements and could be differentially regulated by an intragenic CCCTC binding factor (CTCF)-dependent chromatin loop.
RNASE4 ribonuclease A family member 4 - NIH Genetic Testing …
Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr, Hu GFLi S, et al. Angiogenesis, 2013 Apr. PMID 23143660.