RhoG (R as ho mology G rowth-related) (or ARGH) is a small (~21 kDa) monomeric GTP -binding protein (G protein), and is an important component of many intracellular signalling pathways.

Mar 30, 2025 · RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Familial Hemophagocytic Lymphohistiocytosis 5 and …

Jun 28, 2023 · Overview of RhoG protein activation and regulation. Extracellular signals lead to the activation of RhoG through integrins and GPCR cell receptors. The activation of RhoG …

Feb 25, 2022 · RhoG belongs to the Rho family of small GTPases, specifically the Rac subfamily. The Rho family is involved in actin–cytoskeletal rearrangements, intracellular membrane …

Cloning and sequence analysis of the human homolog revealed that this putative new small GTPase, referred to as rhoG, is more closely related to the rac, CDC42, and TC10 members …

Jun 28, 2023 · This review focuses on the cellular functions of RhoG, interconnecting different signaling pathways, and speculates the importance of this small GTPase as a prospective …

Apr 15, 2021 · RhoG deficiency abrogates cytotoxic function of CTLs and NK cells, causing HLH. RhoG interacts with Munc13-4 at the surface of cytotoxic granules to promote their anchoring …

Feb 8, 2025 · RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1. C-terminal basic tail of …

Jun 6, 2008 · This study provided evidence that constitutively active RhoG (RhoG G12V) stimulated endogenous Rac through ELMO and DOCK180, leading to morphology changes …

Mar 23, 2023 · CRISPR/Cas9-, siRNA-, and pharmacologic-mediated knockdown of the RHOG gene in control CD8+ T and NK cells also reduced the cytotoxic efficiency of these cells, …