Reelin, encoded by the RELN gene, [5] is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. [6]

During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As ...

Jul 29, 2024 · Early in life, the protein Reelin helps assemble the brain. Later on, it appears to protect the organ from Alzheimer's and other threats to memory and thinking.

Reelin activates a number of neuronal signal transduction pathways in the adult central nervous system (CNS) that subsequently modulate synaptic function and plasticity.

Jun 19, 2023 · Mechanistically, Reelin is a large secreted glycoprotein that binds to several membrane receptors, including ApoER2, VLDLR, integrins, and ephrins. Reelin signaling depends on the cell type but mostly involves phosphorylation of NF-κB, PI3K, AKT, or JAK/STAT.

Mar 30, 2025 · RELN (Reelin) is a Protein Coding gene. Diseases associated with RELN include Epilepsy, Familial Temporal Lobe, 7 and Lissencephaly 2. Among its related pathways are Nervous system development and PI3K-Akt signaling pathway.

Reelin is a conserved extracellular glycoprotein crucial for neurodevelopment. In adulthood, Reelin is an important modulator of NMDA receptor-mediated neurotransmission, required for synaptic plasticity, learning and memory.

Dec 7, 2004 · Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing ...

The RELN gene provides instructions for making a protein called reelin. This protein is produced in the brain both before and after birth. Reelin is released by certain brain cells. After being released, it attaches (binds) to specific receptor proteins.

Jul 29, 2024 · A trio of studies published in the past year all suggest that the protein Reelin helps maintain thinking and memory in ailing brains, though precisely how it does this remains uncertain. The studies also show that when Reelin levels fall, neurons become more vulnerable.