Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of …

Ras-related C3 botulinum toxin substrate 2 (Rac2) is a 21 kDa GTPase encoded by 192 amino acids that acts as a molecular switch in a variety of cellular events that include cell motility, …

Circulating neutrophils are persistently higher in mice deficient in the small GTPase Rac2 than in wild-type (WT) mice. Therefore, we examined the mechanisms through which the small …

Mar 30, 2025 · RAC2 (Rac Family Small GTPase 2) is a Protein Coding gene. Diseases associated with RAC2 include Immunodeficiency 73A With Defective Neutrophil Chemotaxis …

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency. The Rac2 GTPase contributes to …

Jun 8, 2022 · We have carried out conditional gene targeting to achieve hematopoietic stem cell (HSC)– or T-cell lineage–specific deletion of Rac1 or Rac1/Rac2 by crossbreeding the Mx-Cre …

Feb 9, 2025 · Title: A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency. The Rac2 GTPase …

While the genetic absence of Rac2 did not affect osteoclast survival, Rac2 −/− osteoclasts showed reduced basal resorptive activity and a clear defect in the ability to respond to the …

Apr 11, 2024 · Dominant and recessive RAC2 mutations differentially perturb RAC2 functions leading to a spectrum of clinical phenotypes. We report 23 unique RAC2 mutations among 54 …

Aug 17, 2020 · The RAC2 gene encodes a member of the RHO family of GTPases, which are a group of cellular signaling molecules that bind downstream effectors to activate a variety of …

Apr 11, 2024 · RAC2 is a highly conserved rat sarcoma virus (RAS)-related GTPase whose expression is limited primarily to immune cells and lymphoid tissue.

RAC2 is a small GTPase that cycles between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAC2 binds to effector proteins to regulate cellular processes, …

Feb 8, 2025 · Rac2 to modulates the level of Rac1-dependent macrophage IL-1beta expression, which consequently determines extent of atherosclerotic calcification. Rac1 and Rac2 have …

Nov 10, 2016 · In experimental atherogenesis, Rac2 prevented progressive calcification through its suppression of Rac1-dependent macrophage interleukin-1β (IL-1β) expression, which in …

Rac2 is important for chemotaxis, superoxide production, and phagocytosis in hematopoietic cells. Rac2 is a major regulator of IL-1β expression , in part via the suppression of Rac1’s activation …

Oct 2, 2009 · Acute lung injury (ALI) is an inflammatory disorder associated with recruitment and activation of neutrophils in lungs. Rac2, a member of the Rho GTPase subfamily, is an …

Jun 2, 2010 · Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J. Cell Sci 119, 2749-2757. Crossref, Medline, Google Scholar; Wu S. S., Jacamo …

Jan 1, 2010 · The best situation is reached when rac1 and rac2 are close, i.e. when the driver operates closer to linear region. In real world the characteristics of the PMOS and NMOS …

Using a targeted genetic deletion, we show that the S100A4 metastasis factor is required for macrophage recruitment to sites of inflammation in vivo. S100A4 −/− primary macrophages …

THE EXAMINATION AND CERTIFICATION OF SEAFARERS TP 2293E 2 of 388 General 1.1 Reference to Act and Regulations 1) The Marine Personnel Regulations were made by the …