Jan 10, 2007 · Retinal degeneration 10 (rd10) mice are a model of autosomal recessive retinitis pigmentosa (RP), identified by Chang et al. in 2002 (Vision Res. 42:517-525). These mice carry a spontaneous mutation of the rod-phosphodiesterase (PDE) gene, leading to a rod degeneration that starts around P18.

We characterize the in vivo changes over time in the retinal structure of wild-type mice alongside two lines of mice deficient in the β-subunit of phosphodiesterase (rd1 and rd10 mice) using spectral domain optical coherence tomography (SD-OCT). ...

004297 B6.CXB1- Pde6b rd10 /J Retinal degeneration 10 ( rd10 ) is a spontaneous missense point mutation in Pde6b (cGMP phosphodiesterase 6B, rod receptor, beta polypeptide).

Using RNA-Seq, we present the first retinal transcriptome analysis of the rd10 murine model of retinal degeneration. Results. Our data confirm the loss of rod-specific transcripts and the increased relative expression of Müller-specific transcripts, emphasizing the important role of reactive gliosis and innate immune activation in RP.

The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This model produces cell death more slowly than others caused by PDE6 loss of function, making it of …

Mar 13, 2018 · Here, we established two mouse models of end-stage retinal degeneration with immunodeficiency, NOG- rd1-2J and NOG- rd10, and characterized disease progress and immunodeficient status.

Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodeficiency, NOG-rd1 …

Two commonly used models for studying RD are rd1 and rd10 mice characterized by a nonsense (rd1) and a missense (rd10) mutation in the gene encoding the β-subunit of rod phosphodiesterase-6...

Feb 1, 2022 · Our data show that the dark-reared rd10 mutant mouse is extremely sensitive to low-intensity light and may not be a suitable model for studies that employ longitudinal in vivo retinal imaging or other functional assessment which require normal room lighting.

Oct 5, 2018 · The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This model produces cell death more slowly than others caused by PDE6 loss of function, making it of particular interest for studying potential therapeutics. …