Rac and Cdc42 Induce Actin Polymerization and G1 Cell ... - Cell …
Nov 1, 1996 · Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65 PAK and are unable to activate the JNK MAP kinase pathway. However, …
Signals from the Ras, Rac, and Rho GTPases Converge on the Pak …
Rac also has multiple effectors, one of which is the serine threonine kinase Pak (p65 Pak). Here we show that Ras, but not Raf, activates Pak1 in cotransfection assays of Rat-1 cells but not …
Rac/Cdc42 and p65PAK Regulate the Microtubule ... - ScienceDirect
Jan 19, 2001 · Phosphorylation is specifically mediated by the small GTPases Rac and Cdc42 and their common downstream target, the serine/threonine kinase p65PAK. Both GTPases …
that rac and cdc42 can interact with the regulatory domain of p65 PAK, a novel and ubiquitous serine/threonine protein kinase (Manser et al., 1994), but whether p65 PAK is involved in rac …
A Conserved Binding Motif Defines Numerous Candidate Target …
Dec 8, 1995 · A search of the GenBank™ data base for similarity with the minimum Cdc42/Rac interactive binding (CRIB) region of a potential effector protein p65 PAK has identified over 25 …
A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65
Nov 7, 1997 · We also show that a mutant of p65 PAK, PAK/RD, lacking the kinase domain but containing the Cdc42/Rac interactive binding (CRIB) region, suppresses transcription via a …
A new Rac target POSH is an SH3‐containing ... - The EMBO Journal
Mar 2, 1998 · Two Rac targets, p65 PAK and MLK, are ser/thr kinases that have been reported to be capable of activating the JNK pathway. We present evidence that neither is the Rac target …
Toll-like receptor 2–mediated NF-κB activation requires a Rac1 ...
Tyrosine phosphorylation of TLR2 is required for assembly of a multiprotein complex that is necessary for subsequent NF-κB transcriptional activity. A signaling cascade composed of …
Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle …
Nov 1, 1996 · Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65 PAK and are unable to activate the JNK MAP kinase pathway. However, …
A novel serine kinase activated by rac1/CDC42Hs-dependent ...
We identified three proteins in neutrophil cytosol of molecular size 65, 62 and 68 kDa which interact in a GTP-dependent manner with racl and CDC42Hs, but not with rho. Purification of …