R-spondin-1 is a secreted protein that in humans is encoded by the RSPO1 gene, found on chromosome 1. [5] In humans, it interacts with WNT4 in the process of female sex development.

Oct 18, 2021 · R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4) that have appeared as multipotent signaling ligands. The best-known molecular …

Mar 22, 2012 · Because R-spondins are potent stimulators of adult stem cell proliferation in vivo and in vitro, these findings might guide the therapeutic use of R-spondins in regenerative …

Jun 22, 2018 · The four R-spondins (RSPO1-4) strongly potentiate Wnt signaling and play critical roles in normal development, adult stem cell survival, and cancer development and …

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin signaling pathway. These proteins are approximately 35 kDa, and are characterized by two …

R-spondins (Rspos) are cysteine-rich secreted glycoproteins which control a variety of cellular functions and are essential for embryonic development and tissue homeostasis. R-spondins …

R-spondins (RSPOs) are a group of secreted proteins that enhance Wnt/β-catenin signaling and have pleiotropic functions in development and stem cell growth. LGR5, an orphan receptor of …

Feb 10, 2025 · R-Spondin proteins have garnered significant attention due to their crucial roles in biological processes. Their involvement in tissue function and potential link to cancer …

R-spondins (RSPOs) are secreted cysteine-rich glycoproteins that belong to a superfamily of thrombospondin type 1 repeat-containing proteins. RSPOs together with WNT proteins …

R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene. [5][6][7] This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the …