Pyrogen may refer to: Pyrogen (fever), a fever inducing substance. Pyrogen (pyrotechnics), a pyrotechnic composition producing flame when heated by e.g. a bridgewire

pyrogen Any substance that causes fever. Endogenous pyrogens are proteins, such as interleukin-1, released by white blood cells in response to bacterial or viral infections.

Pyrogens are fever-inducing substances, such as lipopolysaccharides (LPS) from Gram-negative bacteria (endotoxins), representing significant hazards as contaminants of health products (Montag-Lessing et al., 2010; Daneshian et al., 2008).

The USP now recognizes two tests - The Pyrogen Test conducted with rabbits and the Bacterial Endotoxins Test, also termed the Limulus Amebocyte Lysate (LAL) Test. Additionally, the agency has...

Being sterile means being free from microorganisms and being pyrogen-free means being free from fever-causing substances. The difference can be likened to insects and their eggs. Since some insecticides can only kill insects but not their eggs, it is possible for an apartment to be free from insects but not free from their eggs.

…protein and polysaccharide substances called pyrogens, released either from bacteria or viruses or from destroyed cells of the body, are capable of raising the thermostat and causing a rise in body temperature. Fever is a highly significant indicator of disease. …system’s responses is to produce pyrogens.

Today, bacterial pyrogens \b)\ are recognized as the causative agent responsible for many of those early fevers and for many of the other biological effects described incidental to parenteral...

A pyrogen is a substance causing induction of a febrile response (elevation of body temperature, fever) which can be fatal in humans and animals. The causal substance is usually a bacterial endotoxin, the lipopolysaccharide complex associated with the outer membrane of Gram-negative pathogens including, but not limited to, Escherichia coli ...

Pyrogens refer to substances, often of biological origin, that cause fever in living organisms by stimulating the release of inflammatory cytokines. One well-studied pyrogen is lipopolysaccharide (LPS), found in the membrane of gram-negative bacteria. From: Characterisation and Design of Tissue Scaffolds, 2016

Oct 16, 2022 · Pyrogen or bacterial endotoxin testing are FDA-approved method of determining pyrogenic elements like endotoxin. These tests are essential for decreasing the risk of cross-infection in patients. Pyrogen testing differs from sterility testing, and both tests should be carried out simultaneously.