Dec 7, 2022 · Utilizing a two-stage proteome-wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain proteomes from the dorsolateral prefrontal cortex, including ROSMAP (N = 376) in the discovery stage and Banner (N = 152) in the confirmation stage. In the following, Bayesian colocalization ...

Aug 8, 2022 · We conducted a proteome-wide association study (PWAS) in which we integrated human brain proteomes from discovery (Banner; N = 152) and validation (ROSMAP; N = 376) datasets with genome-wide...

Prince William Art Society (PWAS) is a group of local artists in Prince William County in Northern Virginia dedicated to an appreciation of the visual arts and fine crafts of local artists and this is their Blog, Artistry Spin. Find information about and by PWAS, our events, our Scholarship Program, our artists, our art shows and exhibits plus ...

Apr 12, 2021 · Replication human brain proteomes were profiled from the dPFC of postmortem brain samples donated by 198 European participants of the Banner Sun Health Research Institute (Banner).

Apr 14, 2023 · Results: In PWAS, two statistically significant proteins were identified using the ROS/MAP and then replicated using the Banner reference dataset, including CPT2 (PPWAS-ROS/MAP = 4.15 × 10 -2 and PPWAS-Banner = 3.38 × 10 -3) and APOL2 (PPWAS-ROS/MAP = 4.49 × 10 -3 and PPWAS-Banner = 8.26 × 10 -3).

Jul 14, 2020 · PWAS can capture complex modes of heritability, including recessive inheritance. A comparison with GWAS and other existing methods proves its capacity to recover causal protein-coding genes and highlight new associations. PWAS is available as a command-line tool.

Jul 27, 2022 · Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a proteome-wide association study (PWAS) analysis.

Additionally, we used FUSION pipeline to perform proteome-wide association study (PWAS) and transcriptome-wide association study (TWAS) by integrating GWAS summary data with two different proteome reference weights (ROS/MAP and Banner) and Rnaseq gene expression reference weights, respectively.

Nov 1, 2024 · The annual Banner Art Competition in Manassas, VA has begun. Get your banner entry in before January 31, 2025.

Jul 18, 2024 · We performed proteome-wide association studies (PWAS) and colocalization analyses to identify genes whose cis-regulated brain protein abundances were associated with obesity-related traits,...