The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations indicated that they could be involved in many processes by binding corresponding motifs in the 3′UTR or …

Here, we discuss the evolution, biological function and mechanisms of action of the PUF protein family, and suggest that a primordial function of PUF proteins is to sustain mitotic proliferation of stem cells.

Jan 30, 2018 · The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations indicated that they could be involved in many processes by binding corresponding motifs in the 3'UTR or by interacting with other proteins.

Mar 1, 2002 · Proteins that bind to those sites are key players in controlling mRNA stability, translation and localization. One family of regulatory proteins – the PUF proteins – are not only structurally related, but also bind to 3′UTRs and modulate mRNA expression in a wide variety of eukaryotic species.

Oct 23, 2019 · The Puf family consists of (named after the founding members—Pumilio (Pum) in Drosophila melanogaster and fem binding factor (FBF) in Caenorhabditis elegans ) evolutionarily conserved RBPs that act as post-transcriptional regulators across eukaryotes .

Jun 8, 2017 · Members of the yeast family of PUF proteins bind unique subsets of mRNA targets that encode proteins with common functions. They therefore became a paradigm for post-transcriptional gene control.

Jun 30, 2020 · The Puf superfamily (PufSF) of proteins encompasses a class of eukaryotic RNA-binding proteins (RBPs), which interact with the 3′-untranslated regions (3′-UTRs) of mRNA in the cytosol or with the precursors of rRNA molecules in the nucleolus [1,2,3].

Mar 9, 2010 · Puf proteins have important roles in controlling gene expression at the post-transcriptional level by promoting RNA decay and repressing translation. The Pumilio homology domain (PUM-HD) is a conserved region within Puf proteins that …

The PUF proteins constitute an evolutionarily highly conserved family of proteins present from yeast to humans and plants, and are characterized by a highly conserved C-terminal RNA-binding domain, composed of eight tandem repeats.

A physical unclonable function (sometimes also called physically-unclonable function, which refers to a weaker security metric than a physical unclonable function [citation needed]), or PUF, is a physical object whose operation cannot be reproduced ("cloned") in physical way (by making another system using the same technology), that for a given ...