Patched Domain-Containing Protein 4 (PTCHD4) is a protein, which in humans is encoded by the Patched Domain-Containing Protein 4 gene. It is otherwise known by the aliases: [1] PTCHD4, C6orf138, dj402H5.2, and by the accession number BC137364. [2]

Mar 30, 2025 · PTCHD4 (Patched Domain Containing 4) is a Protein Coding gene. Diseases associated with PTCHD4 include Bardet-Biedl Syndrome 9 and Adult Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include hedgehog receptor activity. An important paralog of this gene is PTCHD1.

Jul 8, 2024 · Here, we report a robust m6A modification of PTCHD4 mRNA, encoding Patched Domain-Containing Protein 4, in senescent cells. The METTL3/METTL14 complex was found to incorporate the m6A modification on PTCHD4 mRNA; addition of m6A rendered PTCHD4 mRNA more stable and increased PTCHD4 production.

May 9, 2024 · Here, we report a robust m 6 A modification of PTCHD4 mRNA, encoding Patched Domain-Containing Protein 4, in senescent cells. The METTL3/METTL14 complex was found to incorporate the m 6 A modification on PTCHD4 mRNA; addition of m 6 A rendered PTCHD4 mRNA more stable and increased PTCHD4 production.

Nov 11, 2023 · Here we conclude that the upregulation of PTCHD4-AS inhibits proliferation and increases CDDP sensitivity of GC cells via binding with MSH2-MSH6 dimer, activating the ATM-p53-p21 pathway. Keywords: gastric cancer, long non-coding RNA PTCHD4-AS, DNA mismatch repair proteins, MSH2-MSH6, cisplatin.

PTCHD4 is a prognostic marker in Glioblastoma multiforme, Kidney chromophobe, Kidney renal clear cell carcinoma, Kidney renal papillary cell carcinoma

Patched proteins, such as PTCHD4, are characterized by an evolutionarily conserved arrangement of 12 transmembrane domains and a sterol-sensing domain. PTCHD4 is a p53 (TP53; 191170) target that can suppress the oncogenic hedgehog (see SHH, 600725) pathway (Chung et al., 2014).

Feb 8, 2025 · patched domain-containing protein 4, p53-regulated patched protein, patched domain-containing protein C6orf138. Data indicate that tumor suppressor p53 can suppress canonical Hedgehog signaling via induction of patched domain …

View mouse Ptchd4 Chr17:42626838-42815968 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

PTCHD4 - Explore an overview of PTCHD4, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.