Sep 7, 2021 · The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating...

Apr 15, 2021 · Water-soluble, biodegradable, nonionic, and biocompatible polymers with multiple functional groups are highly desired for biomedical applications. Here, we report that water-soluble nonionic poly (d / l -serine) is chirality-controllable, biodegradation-controllable, and …

Thiol-based cross-linkers and ionic-liquid-based cationic cross-linker are employed for the gelation of acryl-functionalized P (AcSer). The obtained polypeptide gel materials exhibit excellent swelling behaviors in organic/aqueous media.

These water-soluble poly (L-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.

Sep 10, 2012 · These water-soluble poly (L-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.

Poly (l -serine) (polySer) has tremendous potential as a polypeptide-based functional material due to the utility of the hydroxyl group on its side chain; however, tedious protection/deprotection of the hydroxyl groups is required for its synthesis.

Apr 15, 2021 · Here, we report that water-soluble nonionic poly (d/l-serine) is chirality-controllable, biodegradation-controllable, and non-cytotoxic. Hence, it can be a highly sought-after alternative to...

Nov 23, 2015 · Non-ionic water-soluble poly-dl-serine (PSer) was synthesized from an activated urethane-type derivative of serine. SEC, NMR and MALDI-ToF analyses of the polypeptides revealed a controllable polymerization initiated by primary or secondary amines.

Nov 14, 2003 · Sericin model peptides such as poly (l -serine) (11, 12, 13, 14, 15, 16), poly (O -benzyl- l -serine) (12), and poly (O -acetyl- l -serine) (13, 14) were synthesized for structural feature characterization. The ability of poly (l -serine) to fold into a β conformation depended on molecular weight.

In summary, we design poly-DL-serine (PSer) as a class of anti-FBR materials that are composed of L-serine and D-serine, which is inspired by the high L-serine content in silk sericin and the high level of D-serine in the human body as an important neurotransmitter altogether.