PolG disease is a genetic disorder that robs the body’s cells of energy, in turn causing progressive multiple organ dysfunction and failure. One might compare it to having a faulty battery that …

DNA polymerase subunit gamma (POLG or POLG1) is an enzyme that in humans is encoded by the POLG gene. [5] Mitochondrial DNA polymerase is heterotrimeric, consisting of a …

POLG mutations are the most common cause of inherited mitochondrial disorders, with as many as 2% of the population carrying POLG mutations. POLG -related disorders comprise a …

The POLG Foundation supports and accelerates research to find effective treatments and a cure for PolG-related mitochondrial disorders.

Mar 11, 2025 · PolG disease is genetic condition that depletes the body’s cells of energy. This in turn causes progressive multiple organ dysfunction and failure.

Prince Frederik of Luxembourg died at the age of 22 due to a rare mitochondrial condition called POLG disease— Newsweek has rounded up what you need to know about the illness.

Mar 11, 2025 · A 22-year-old young prince of Luxembourg, Prince Frederik, died from a rare genetic disease called POLG, according to a statement issued by his parents, Prince Robert …

This Review describes the clinical features, pathophysiology, natural history and treatment of POLG-related disorders, focusing particularly on the neurological manifestations of these …

The POLG gene provides instructions for making the active piece, called the alpha subunit, of a protein called polymerase gamma (pol γ). Learn about this gene and related health conditions.

Mar 10, 2025 · What is POLG? POLG disease is a mitochondrial disorder caused by inherited mutations in the POLG gene—which is critical to the processes of replicating cells’ genetic …