The POGZ gene provides instructions for making a protein that is found in the cell nucleus. The POGZ protein is part of a group known as zinc finger proteins, which contain one or more …

Feb 26, 2020 · Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental …

Mar 30, 2025 · POGZ (Pogo Transposable Element Derived With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include White-Sutton Syndrome and …

Pogo transposable element with ZNF domain is a protein that in humans is encoded by the POGZ gene. [5][6] The protein encoded by this gene appears to be a zinc finger protein containing a …

Nov 17, 2020 · Here, we generate a brain specific conditional knockout mouse model deficient for Pogz, an ASD risk gene. We demonstrate that Pogz deficient mice show microcephaly, growth …

The POGZ protein (pogo transposable element-derived protein with zinc finger domain) is a heterochromatin protein 1α (HP1α)-binding protein, which destabilizes the interaction between …

Aug 29, 2023 · Sun et al. show that the top neurodevelopmental disorder risk factor POGZ is required to suppress retrotransposable elements in embryonic stem cells and during ESC …

Dec 7, 2021 · Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum …

POGZ-related syndrome is an autosomal dominant genetic condition. This means that when a person has the one damaging variant in POGZ they will likely have symptoms of POGZ …

Feb 26, 2020 · In this study, we developed the first mouse model that carried a pathogenic de novo mutation of POGZ identified in an ASD patient. From the same patient, we established …