The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (protein kinase B).

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence , proliferation , cancer , and longevity.

The PI3K/Akt/mTOR pathway can be targeted by a variety of approaches including: (i) targeting kinases that lead to activation of Akt, PI3K and PDK-1, (ii) directly targeting PI3K, (iii) directly inhibiting Akt, (iv) targeting downstream effectors of Akt …

Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).

Nov 21, 2024 · The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of cell survival, growth, and proliferation and is among the most frequently mutated pathways in cancer. However, where and how PI3K-AKT signaling is spatially activated and organized in mammalian cells remains …

In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies consisting of signaling inhibitors and conventional cancer therapies.

Mar 12, 2025 · Explore the PI3K-Akt pathway’s role in cellular regulation, its impact on cancer biology, and the potential of targeted therapeutic interventions. Cell signaling pathways regulate essential cellular processes, and the PI3K-Akt pathway plays a central role in cell growth, survival, and metabolism.

The PI3K-AKT pathway is an intracellular signaling system that, in response to external cues, encourages metabolism, proliferation, cell survival, growth, and angiogenesis. From: Experimental and Molecular Pathology, 2023

Nov 30, 2009 · The role of PI-3-K in the regulation of mitochondrial functions is becoming a field that draws attentions from cancer as well as metabolic diseases. In this review, we focus on the action of the major downstream target of PI-3-K, the serine/threonine kinase AKT, a …

AKT/PI3K is one of the most actively studied kinase pathways in basic research and drug development, as it plays an integral role in mediating signals for cell growth, survival, cell-cycle progression, differentiation, transcription, translation, and glucose metabolism (See figure 1).