PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). [7] [8] …

Mar 30, 2025 · This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to …

The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family, was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a wide range …

PAK1 is a promising therapeutic target in cancer and allergen-induced disorders. Its suitability as a target in vascular, neurological and infectious diseases remains ambiguous.

Mar 8, 2025 · HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by …

Aug 1, 2020 · Here, we provide an overview of essential roles that PAK1 plays in cancer, including its structure and autoactivation mechanism, its crucial function from onset to …

p21-activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers …

This review describes PAK family proteins, their biological functions, and their role in regulating aging and longevity using C. elegans. Moreover, we discuss the effect of small-molecule PAK1 …

Oct 9, 2023 · In this study, we show that SARS-CoV-2 cell entry promotes ACE2 endocytosis and degradation. The ACE2-spike complex is internalized by clathrin-mediated endocytosis and …

Mar 10, 2025 · Pak1 regulates cardiac function, adipose tissue metabolism, and pancreatic β-cell survival and function. Inflammation, oxidative stress, and Hippo signaling link Pak1 dysfunction …