PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer and …
In this study, we constructed three different PTK7-specific CAR (PTK7-CAR1/2/3), each comprising a humanized PTK7-specific single-chain variable fragment (scFv), hinge and …
Therapeutic Targeting of PTK7 is Cytotoxic in Atypical Teratoid ...
Here, we examine the therapeutic efficacy of Vatalanib in the treatment of ATRT and a potential target for treatment known as Protein Tyrosine Kinase 7 (PTK7), which we found by …
Identification and targeting of protein tyrosine kinase 7 (PTK7) as …
We developed an anti-PTK7 chimeric antigen receptor (CAR) and find PTK7 CAR T cells specifically target and kill PTK7-expressing neuroblastoma in vitro. In vivo, human/murine …
Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell …
Results: PTK7 controls cellular protrusions and, as a result, directional cell motility and metastasis in fibrosarcoma HT1080 cells. Conclusion: Both PTK7 expression and proteolysis contribute to …
Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 …
Jul 20, 2023 · We targeted protein tyrosine kinase 7 (PTK7), a prominent cancer marker, and demonstrated aptamer-mediated biotin transfer to specific lysine residues on the extracellular …
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate …
Dec 18, 2015 · Among WNT/PCP components, protein tyrosine kinase 7 (PTK7) is a tyrosine kinase receptor with poorly defined functions lacking catalytic activity. Here we show that …
Results: PTK7 and ROR2 form a heterodimeric complex and bind to WNT5A, promoting JNK phosphorylation and regulating expression of paraxial protocadherin. Conclusion: PTK7 and …
PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer ... - PubMed
Aug 12, 2021 · Using in vivo xenograft models of lung cancers with different expression levels of PTK7, systemic delivery of PTK7-CAR2 modified T cells significantly prevented tumor growth …
PTK7 proteolytic fragment proteins function during early Xenopus ...
Sep 1, 2019 · PTK7 proteolytic fragment proteins act like full-length PTK7 to support canonical Wnt-signaling by maintaining LRP6 protein levels. Protein Tyrosine Kinase 7 (PTK7) is as a …
PTK7 - Wikipedia
PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) …