Understand the toxic moiety is important to application of KMD. Usually KMD is determined based on sparse IED data. Using in vitro methods and computational modeling, we may be able to …

Jun 1, 2020 · The GLP developmental toxicity study in rabbits did not produce evidence of maternal or fetal toxicity at the highest dose tested (32 mg/kg/day) but pharmacokinetics (PK) …

Integration of TK was instrumental in selecting the most relevant dose levels for critical RinskorTM guideline dietary toxicity studies leading to a KMD approach instead of the traditional toxicity …

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The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not …

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PK/TK encompasses the measurement and elucidation of mecha-nisms by which organisms interact with chemicals in their environment, i.e., the way organisms absorb, distribute, …

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