Regulating IRFs in IFN Driven Disease - PMC
Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family …
Differential and Overlapping Immune Programs Regulated by IRF3 …
Nov 15, 2018 · Transcriptomic analyses of pDCs show that the partitioning of TLR7/IRF5 and RLR/IRF3 pathways confers differential gene expression and immune cytokine production in …
An integrin axis induces IFN-β production in plasmacytoid …
Posttranslational activation of mTOR signaling pathway and phosphorylation of p70S6 kinase lead to enhanced Irf3 mRNA transcription. IRF3 protein is phosphorylated and translocated to the …
Interferon regulatory factor 3 as key element of the interferon ...
Nov 7, 2014 · Our findings suggest that the predominant IRF3 expression on circulating pDC is a key element for the increased IFN-α activation based on the interplay between the rs2304206 …
The multiple roles of interferon regulatory factor family in health …
Oct 9, 2024 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, …
Human plasmacytoid dendritic cells elicit a Type I Interferon …
Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN) and are important for host defense by sensing microbial DNA via TLR9. pDCs also play a critical role in the …
IRF family proteins and type I interferon induction in ... - Nature
Feb 13, 2006 · IRF-3, although contributes to IFN induction in fibroblasts, is dispensable in IFN induction in DC. Our recent evidence reveals that type I IFN induction in DC is critically …
IRF3-binding lncRNA-ISIR strengthens interferon production in …
Nov 2, 2021 · Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its …
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3 ...
Jul 25, 2022 · By developing a genetic code expansion orthogonal system, we demonstrated the presence of an acetyl moiety at specific IRF3/IRF7 DBD site/s abolish IRF3/IRF7 LLPS and …
Regulation of immunity and oncogenesis by the IRF transcription …
Upon virus infection, RIG-I- or MDA5-activated TBK1 phosphorylates IRF3 at Ser396, 398, 402, 404, and 405 in site 2 of the carboxy (C)-terminal regulatory region, which alleviates auto …
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