Jul 31, 2021 · Luteinizing hormone and chorionic gonadotropin are essential to human reproduction and are important therapeutic drugs 3-6 . They activate the same G-protein-coupled receptor, luteinizing hormone-choriogonadotropin receptor (LHCGR), by binding to the large extracellular domain 3 .

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7FIH: luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex. PDB ID: 7FIH Download: MMDB ID: 206998: PDB Deposition Date: 2021/7/31: Updated in MMDB: 2024/10: Experimental Method: electron microscopy. Resolution:

The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR), is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as …

Luteinizing hormone subunit beta also known as lutropin subunit beta or LHβ is a polypeptide that in association with an alpha subunit common to all gonadotropin hormones forms the reproductive signaling molecule luteinizing hormone.

Sep 22, 2021 · Here we report four cryo-electron microscopy structures of LHCGR: two structures of the wild-type receptor in the inactive and active states; and two structures of the constitutively active...

Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LHR, LSH-R. SWISSPROT. 7TM. 1178 mutation data points available.

Jul 31, 2021 · Here we report four cryo-electron microscopy structures of LHCGR: two structures of the wild-type receptor in the inactive and active states; and two structures of the constitutively active mutated receptor.

Sep 22, 2015 · We designed an advanced homology model of the hormone/LHCGR complex, followed by experimental characterization of relevant fragments in the hinge region. In addition, we examined predictions of a helical exon10-encoded conformation by block-wise polyalanine (helix supporting) mutations.