Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.

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Mar 25, 2025 · Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease that is the cause of 1-2% of deaths from cirrhosis and constitutes the third most common indication for liver transplantation in adults.

Jul 28, 2022 · PBC has four stages. They’re based on how much damage has been done to the liver. Stage 1. There’s inflammation and damage to the walls of medium-sized bile ducts. Stage 2. There’s blockage of...

PBC is a rare and progressive cholestatic liver disease. Although several treatment options have been investigated, UDCA remains first-line therapy and has proven efficacious in normalizing serum biochemistries and halting the progression of …

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Understand how PBC progresses and risk factors for disease progression and view the latest guidelines for consistent monitoring of treatment response and evaluation for reassessment.

At Real PBC Talk, we’re meeting you where you are in your journey with PBC and giving you the details—from disease education to treatment response and signs of disease progression. Begin here for more information on PBC, including symptoms and …

Primary biliary cholangitis (PBC) is a liver disease that affects the bile ducts that run through your liver. It slowly degrades those bile ducts, making it harder for bile to flow through. Bile backs up inside your liver, which damages the tissues. Scar tissue gradually replaces healthy tissue and your liver gradually loses its functionality.