The Ubiquitination of NF-κB Subunits in the Control of Transcription
Together with the E2 enzyme UbcH3, ING4 was recently found to promote the K48 linked ubiquitination and proteasome-dependent degradation of p65 via its plant homeodomain …
PPARγ is an E3 ligase that induces the degradation of NFκB/p65
Dec 18, 2012 · Ligands or agonists of PPARγ (for example, TROG, PIOG) induces PPARγ binding to p65, which subsequently transfers the K48-linked polyubiquitin to p65 promoting its …
Ubiquitin Specific Protease USP48 Destabilizes NF-κB/p65 in …
We described that USP48 downregulation stabilizes p65. Notably, the accumulation of p65 is mainly detectable in the nuclear compartment and it is accompanied by an increased NF-κB …
The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine ...
Aug 21, 2019 · Mechanistically, RNF182 promotes the degradation of p65 via K48-linked ubiquitination, resulting in the inhibition of TLR-triggered innate immune responses. Our …
20-hydroxyecdysone suppresses bladder cancer progression via
Mechanistic studies showed that USP21 directly interacted with and stabilized p65 by deubiquitinating its K48-linked polyubiquitination in bladder cancer cells, which could be …
A Method for the Quantitative Analysis of Stimulation-Induced …
Here, we provide a method to obtain patient-derived dermal fibroblasts and quantitatively assess the integrity of the signal transduction pathway from receptor activation to nuclear p65 …
Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits …
Dec 1, 2013 · p65/p50 is a crucial transcription factor in the NF-κB pathway and host innate immune system. Many viruses, including RNA and DNA viruses, antagonize the host …
FR promotes the K48-linked ubiquitination of p65 by recruiting …
FR promotes the K48-linked ubiquitination of p65 by recruiting the E3 ubiquitin enzyme RNF182. Tenocytes were silenced with RNF182 siRNA (A), ING4 siRNA (B), or PPARγ siRNA (C) for …
Vangl2 suppresses NF-κB signaling and ameliorates sepsis by …
Mechanistically, NF-κB signaling-induced-Vangl2 recruits E3 ubiquitin ligase PDLIM2 to catalyze K63-linked ubiquitination on p65, which serves as a recognition signal for cargo receptor …
TRIM21 interacts with IκBα and negatively regulates
Apr 1, 2025 · Our data showed that C. pseudotuberculosis infection resulted in the increase of total protein ubiquitination, and K48-linked ubiquitination of IκBα, whereas it had no obvious …