Aug 7, 2020 · Pyrroline-5-carboxylate synthase (P5CS) is a mitochondrial-localized bifunctional enzyme that exhibits glutamate kinase (GK) and γ-glutamyl phosphate reductase (GPR)...

Nov 6, 2024 · Here we show that when cellular dependence on OXPHOS increases, pyrroline-5-carboxylate synthase (P5CS)—the rate-limiting enzyme in the reductive synthesis of proline …

Pyrroline-5-carboxylate synthase (P5CS) is a bifunctional enzyme that exhibits glutamate kinase (GK) and γ-glutamyl phosphate reductase (GPR) activities. The enzyme is highly relevant in …

1-Pyrroline-5-carboxylic acid (systematic name 3,4-dihydro-2H-pyrrole-2-carboxylic acid[2]) is a cyclic imino acid. Its conjugate base and anion is 1-pyrroline-5-carboxylate (P5C). In solution, …

May 13, 2024 · Delta-1-pyrroline-5-carboxylate synthase (P5CS) is a rate-limiting enzyme in proline synthesis, catalysing the initial two-step conversion from glutamate to proline 8. Here …

Mar 14, 2022 · Using cryo-electron microscopy (cryo-EM), here we solve the structures of full-length P5CS in multiple filamentous states. We reconstruct Drosophila P5CS structures at …

P5CS is a bifunctional enzyme encoded by the P5CS gene and has originated from the fusion of the ProB and ProA genes. Previous studies showed that gene fusions are rare, and 31 of the …

Δ (1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis. P5CS deficiency has been reported in three families, with patients presenting …

Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine. P5CS malfunction leads to multiple …

Apr 17, 2024 · With a broad sampling of available DNA sequences and annotated species (526 P5CS sequences from 370 species, 736 ProB sequences from 648 species, and 641 ProA …