Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

Mar 30, 2025 · cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA (Q6I9V6_HUMAN) Cyclin-dependent kinase inhibitor 1B (Q708J1_HUMAN) Graphical View of Domain Structure for InterPro Entry

The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

Sep 1, 2020 · Recent data indicate p27 regulates transcription and acts as a transcriptional coregulator of cJun. C-terminal p27 phosphorylation increases p27-cJun recruitment to and action on target genes to drive oncogenic pathways and repress differentiation programs.

Cyclin dependent kinase inhibitor p27 (also known as KIP 1) is a factor that inhibits the progression of the cell cycle by using specific molecular mechanisms. The inhibitory effect of p27 on the cell cycle is mediated by CDKs inhibition.

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming growth factor (TGF)-β. Since the cloning of the ...

The p27 protein is a global cyclin-dependent kinase inhibitor (encoded in chromosome 12p12–12p13.1) that can bind all essential cdk types to potentially intervene the cellular cycle in several phases, the earliest of which is the restriction point between early (growth factor dependent) G1 and later growth factor independent phases.

Mutations, abnormal expression and mislocalization of p27 have been found in many diseases suggesting the important role of p27 in the pathogenesis of diseases. Human p27 gene ( CDKN1B ) was cloned in 1994 7 and mapped to chromosome 12p13.

Feb 8, 2025 · p27’s tumor suppressor role is linked to its inhibition of cell cycle progression, preventing uncontrolled cell proliferation. By halting the cycle at the G1 phase, p27 allows DNA repair, reducing genomic instability and oncogenesis risk.

p27kip1 is a member of the cdk inhibitory proteins, with an important role coordinating the activation of cyclin E-cdk2 with accumulation of cyclin D-cdk4 and initiating the timely exit of cells from the cell cycle in response to antimitogenic signals. Three features of p27 make it a strong candidate as a target to consider in cancer therapy.