The senescence-associated secretory phenotype and its ... - Nature
Apr 23, 2024 · Both p53–p21 and p16 directly regulate the SASP: p21 supports an early secretory phenotype that includes CXCL14 and IGFBP3, which puts stressed or senescent cells under …
p21 produces a bioactive secretome that places stressed cells
We found that p21—in addition to its function in maintaining the cell-cycle arrest of SNCs—has a prominent role in establishing the SASP through retinoblastoma protein (Rb)–dependent …
p21 produces a bioactive secretome that places stressed cells …
p21 regulates the SASP through Rb-dependent transcription. In our initial screen, we exposed primary mouse embryonic fibroblasts (MEFs) to three distinct senescence-inducing stressors: …
The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in …
The p21-induced secretome is characterized by the release of additional immunosurveillance factors, in particular Cxcl14, which are lacking in the p16INK4A-induced SASP. Consequently, …
The senescence-associated secretory phenotype and its ... - PubMed
Apr 24, 2024 · Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic …
An inducible p21-Cre mouse model to monitor and manipulate p21 ... - Nature
Oct 7, 2021 · The p21-Cre mouse model allows us to suppress the SASP only in p21 high cells, so it is a cleaner system for examining the contribution of the SASP to age-related disorders.
p21 induces a senescence program and skeletal muscle dysfunction
Jan 1, 2023 · We show that p21 induces several core properties of cellular senescence in skeletal muscle, including an altered transcriptome, DNA damage, mitochondrial dysfunction, and the …
Senescence-associated secretory factors induced by cisplatin in ...
Feb 15, 2018 · Here we demonstrated that various melanoma cell lines adopted senescence phenotype after CDDP treatment in contrast to the other types of tumour cells. CDDP …
Cooperation between p21 and Akt is required for p53‐dependent …
Jul 9, 2017 · In this study, we have shown that both Akt and p21 are required to induce cellular senescence in response to p53 expression. In a p53‐induced senescence model, we found …
Sensitive Detection and Monitoring of Senescence-Associated …
Dec 18, 2012 · Etoposide-treated cells exhibited a senescent phenotype characterized by senile morphology, positive staining for senescence-associated β-galactosidase, growth arrest and …