OPN1LW is a gene on the X chromosome that encodes for long wave sensitive (LWS) opsin, or red cone photopigment. [5] The OPN1LW gene provides instructions for making an opsin pigment that is more sensitive to light in the yellow/orange part …

The OPN1LW gene provides instructions for making an opsin pigment that is more sensitive to light in the yellow/orange part of the visible spectrum (long-wavelength light).

Mar 30, 2025 · OPN1LW (Opsin 1, Long Wave Sensitive) is a Protein Coding gene. Diseases associated with OPN1LW include Blue Cone Monochromacy and Colorblindness, Partial, Protan Series. Among its related pathways are GPCR downstream …

Identification of one single red-green OPN1LW/MW hybrid gene harboring a point mutation that associates with blue cone monochromatism. The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin mutations.

Feb 8, 2025 · Gene target information for OPN1LW - opsin 1, long wave sensitive (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Apr 3, 2023 · Four classes of variants were identified: haplotypes causing partial splicing defects in OPN1LW (LVAVA or LIVVA in 31 families), LVAVA in OPN1LW-OPN1MW hybrid gene (in 3 families), LIAVA in OPN1LW (in 29 families), and truncations in OPN1LW (in 5 families).

The OPN1LW and OPN1MW genes, located on the X-chromosome at Xq28, encode the protein component of the light-sensitive photopigments expressed in the L and M cones. Diverse haplotypes of exon 3 of the OPN1LW and OPN1MW genes arose thru unequal recombination mechanisms that have intermixed the genes.

Jul 3, 2010 · OPN1LW is a gene located on the X-chromosome responsible for producing the long (L) wavelength or red cone opsin in the visual system. You might find these chapters and articles relevant to this topic. Samantha R. De Silva, ... Omar A. Mahroo.

Nov 9, 2022 · The developed genetic assay for the OPN1LW/OPN1MW gene cluster is a diagnostic test that can detect both structural and nucleotide variants with a straightforward analysis, improving diagnostic...

Dec 10, 2024 · Clinical resource with information about OPN1LW, Cone monochromatism, Protan defect, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.