Jan 24, 2024 · Analysis of NK cells at 24 h post-photoconversion revealed that production of CCL5 was restricted to KG+ CD11b+ CD49a- NK cells, confirming the rapid loss of CCL5 expression after tumor...

Methods: The CCR5-CCL5 axis is critical in NK cell homing to tumor sites. Thus, we analyzed CCR5 expression on NK cells from patients with cancer and healthy donors. We then upregulated CCR5 and CCL5 with lentiviruses and oncolytic viruses in NK and tumor cells, respectively.

Jul 13, 2022 · To identify which NK cell subset produced CCL5, we analyzed CCL5 expression after AdV5–IL-12 treatment in subpopulations of NK cells reflecting different maturation stages and subtypes, defined by CD11b and CD27 expression and by markers associated with homing or tissue residency (28, 29).

Feb 22, 2018 · Here, we show that such tumors are infiltrated by cDC1, and we identify a key role for intratumoral NK cells in producing CCL5 and XCL1 chemokines that promote cDC1 recruitment.

Mar 26, 2020 · Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse...

Mar 20, 2018 · CIBERSORT analysis suggested that a high CCL5 expression was associated with recruitment of CD8 T cells, CD4 activated T cells, NK activated cells and macrophages M1.

Activated NK cells produce XCL1, CCL1, CCL3, CCL4, CCL5, CCL22, and CXCL8. Chemokines secreted by NK cells may recruit other effector cells during immune responses. Furthermore, CCL3, CCL4, and CCL5 produced by NK cells can inhibit in vitro replication of HIV.

Oct 31, 2017 · Clinically, a positive correlation between CCL5 and NK cell marker NKp46 expression was found in melanoma patients, and a high expression level of CCL5 was correlated with a significant improvement of melanoma patients' survival.

Oct 10, 2017 · We provide evidence that driving NK cells to the tumor bed relied on the ability of autophagy-defective tumors to transcriptionally overexpress the chemokine gene CCL5. Such infiltration and tumor regression were abrogated by silencing CCL5 in BECN1-defective tumors.

CCL5 has been shown to induce the in vitro migration and recruitment of T cells, dendritic cells, eosinophils, NK cells, mast cells and basophils.