Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina [1] of parahoxozoans. [2] . Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2). [3] .

May 1, 2022 · As a key molecule in the basement membrane, nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific differentiation.

Nidogen, also known as entactin, is a multifunctional glycoprotein that plays a crucial role in the maintenance of the basement membrane (BM), morphogenesis and neuronal plasticity. This review aims to provide an overview of the structural features, molecular interactions and diverse functions associated with Nidogen.

Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene. [5] [6] Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin [7] and fibronectin. [8]

Mar 14, 2024 · We discuss the current state of knowledge regarding Nidogen's role in tissue maintenance, cell adhesion, migration, and signaling, shedding light on its intricate contributions to physiological and pathological processes.

Nov 10, 2022 · Nidogen-2 is a 200 kDa BM glycoprotein consisting of 3 globular domains (G1 to G3), a rod-like segment between G1 and G2, and an EGF-like domain-containing segment that connects G2 and G3. Nidogen-2 shares 46% sequence homology with nidogen-1.

Platelet adhesion to nidogen-1 activated the IκB kinase (IKK) complex, while pharmacological inhibition of IKK blocked platelet spreading on nidogen. Taken together our results suggest that nidogen may play a redundant role in hemostasis by activating platelets downstream of GPVI.

Apr 2, 2021 · In this review, the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development; the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration, including but not limited to adipogenesis, angiogenesis, chondrogenesis, myogenesis, and neurogenesis.

Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent.

Mar 14, 2024 · Nidogen, also known as entactin, is a multifunctional glycoprotein that plays a crucial role in the maintenance of the basement membrane (BM), morphogenesis and neuronal plasticity.