The NQO1 bioactivatable drug, β-lapachone, alters the redox state …
In this study, a multimodal analysis, including metabolic imaging using hyperpolarized pyruvate, points to reduced oxidative flux due to NAD + depletion after β-lapachone treatment of NQO1+ …
NQO1 targeting prodrug triggers innate sensing to overcome ... - Nature
Jul 19, 2019 · We discovered that after activation by NQO1, β-lap caused tumor-selective cell death and induced innate sensing for adaptive antitumor immunity.
β-lapachone suppresses tumour progression by inhibiting …
Jun 2, 2017 · As a NQO1 activator, β-lap exhibited a novel anti-cancer activity in NQO1-postive breast cancer cells. Additionally, β-lap inhibited breast cancer cell proliferation, invasion and …
Albumin binding revitalizes NQO1 bioactivatable drugs as novel ...
Sep 1, 2022 · NQO1 activatable drugs, such as β-lap, could achieve tumor-selective killing while sparing normal cells lacking NQO1 expression in vitro and showing tumor inhibition in …
An NQO1- and PARP-1-mediated cell death pathway induced in non ... - PNAS
Jul 10, 2007 · Here, we generated isogenically matched NQO1 + and NQO1 − human H596 NSCLC cells and demonstrated that β-lap induces PARP-1-mediated cell death in an NQO1 …
β-Lapachone promotes the recruitment and polarization of tumor ...
Jun 4, 2024 · NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an …
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective …
We show that the NAD (P)H:quinone oxidoreductase 1 (NQO1) bioactivatable drug, β-lapachone (ARQ761, ArQule, in clinical form), capitalizes on elevated NQO1:CAT ratios in recalcitrant …
β-Lapachone, an NQO1 bioactivatable drug, prevents lung …
Jun 15, 2024 · Based on this finding, we utilized β-Lapachone (β-Lap), an NQO1 bioactivatable drug, to suppress lung tumorigenesis. In this study, the efficacy and safety of low-dose β-Lap …
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use …
Dec 12, 2016 · NAD (P)H:quinone oxidoreductase 1 (NQO1) bioactivatable drugs have the potential to deliver tumor-selective DNA damage and cell death. They are a unique class of …
NQO1 targeting prodrug triggers innate sensing to overcome …
NQO1 can be important biomarker since NQO1 is essential and sufficient for β-lap-mediated specific innate sensing and adaptive T cell responses. β-lap is currently being tested in …