Nucleophosmin 1 Mutations in Acute Myeloid Leukemia - PMC
NPM1 is a transcriptional target of MYC [39,40]. MYC overexpression increases protein synthesis; therefore, NPM1 is a key transcriptional target, given its numerous functions. NPM1 controls …
Nucleophosmin 1 cooperates with BRD4 to facilitate c-Myc
Oct 24, 2023 · Mechanistically, NPM1 influences and cooperates with BRD4 to facilitate c-Myc transcription to promote PCa progression. In addition, JQ1, a bromodomain and extra-terminal …
c-MYC stain as a potential minimal residual disease marker for …
Jan 30, 2025 · A 49-year-old woman with history of acute myeloid leukemia (AML) with NPM1 mutation after multiple rounds of chemotherapy was evaluated for minimal residual disease …
Molecules that target nucleophosmin for cancer treatment: an …
Even though amplification of the NPM1 locus has never been shown, the NPM1 gene is a target of the oncogenic c-MYC, which stimulates NPM1 expression by direct binding to the NPM1 …
Nucleophosmin (NPM1) Mutations in Adult and Childhood Acute …
Somatic mutations in exon 12 of the NPM gene (NPM1) are the most frequent genetic abnormality in adult AML, found in approximately 35% of all cases and up to 60% of patients with normal …
In-depth inference of transcriptional regulatory networks reveals NPM1 …
Jan 10, 2025 · Our results revealed an upregulated ribosome (RB) signature in the MYC -amplified G3 subtype and identified NPM1, which exhibited the highest risk of poor prognosis, …
Nucleophosmin 1 cooperates with BRD4 to facilitate c-Myc
Oct 24, 2023 · Mechanistically, NPM1 influences and cooperates with BRD4 to facilitate c-Myc transcription to promote PCa progression. In addition, JQ1, a bromodomain and extra-terminal …
Structure of nucleophosmin DNA-binding domain and analysis of …
Aug 3, 2012 · Here we present the solution structure of the NPM1-C70 domain and NMR analysis of its interaction with a c-MYC-derived G-quadruplex. These data were used to calculate an …
MYC as a regulator of ribosome biogenesis and protein …
MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and...
In-depth inference of transcriptional regulatory networks reveals NPM1 …
Jan 10, 2025 · Inhibition of NPM1 led to apoptosis, reduced c-Myc stability, and impaired translation in MYC-amplified Group 3 MB cells. Together, our findings highlight NPM1 as a …
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