NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44 + immune cells.

Viruses up-regulating/down-regulating NKp44L expression on infected cells are indicated with up and down arrows. Green arrows indicate interactions resulting in NK cell activation, while red...

Oct 24, 2013 · NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand.

In this study we identified a novel 44-kD surface molecule (NKp44) that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2.

Antibodies that detect NKp44 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, ELISA and Functional Assay. These antibodies target NKp44 in Human, Mouse and Rat samples. Our NKp44 monoclonal, polyclonal and recombinant monoclonal...

Jan 28, 2022 · NKp44 is a 44 kDa transmembrane glycoprotein characterized by a single extracellular V-type domain. The transmembrane domain contains the charged amino acid lysine and is involved in the association of NKp44 with the adaptor protein DAP12 containing an ITAM (immunoreceptor tyrosine-based activation motif) for signaling ( 4 , 7 , 8 ).

Mar 1, 1999 · Of these receptors, NKp44 is selectively expressed by IL-2– activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Here we describe the molecular cloning of NKp44.

One important family of activating receptors is the natural cytotoxicity receptors (NCRs) which include NKp30, NKp44 and NKp46. The NCRs initiate tumor targeting by recognition of heparan sulfate on cancer cells. This study aims to elucidate heparan sulfate structural motifs that are important for NCR binding.

Jul 8, 2020 · NKp44 is only expressed by activated natural killer cells and detects a variety of transformed cells, while it reportedly does not react with normal tissues. The aim of this study is to develop CAR-T cell that can target multiple types of tumor cells.

Apr 9, 2019 · NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44 + immune cells.