Many cells, including skeletal muscle fibers, are coated by a layer of extracellular matrix material called the basement membrane (BM). 1 The BM, in turn, is composed of two layers: an internal, felt-like basal lamina (BL) directly linked to the plasma membrane, and an external, fibrillar reticular lamina. BMs contain protein and carbohydrate ...

Oct 15, 2019 · Primary myoblasts are undifferentiated proliferating precursors of skeletal muscle. They can be cultured and studied as muscle precursors or induced to differentiate into later stages of muscle development.

Mar 14, 2018 · Here, we show that upon activation, skeletal muscle stem cells (satellite cells) induce local remodeling of the ECM and the deposition of laminin-α1 and laminin-α5 into the basal lamina of the...

The lamina propria is a thin layer of connective tissue that forms part of the moist linings known as mucous membranes or mucosae, which line various tubes in the body, such as the respiratory tract, the gastrointestinal tract, and the urogenital tract.

Nov 25, 2024 · Here, Lamia et al. showed that the contractile properties of ChR2-EYFP skeletal muscle had aggregated EYFP in sarcolemma, decreased contractile force production, and smaller fibers compared with ChR2-only and WT mice.

Adult skeletal muscle is maintained and repaired by resident stem cells called satellite cells, located between the plasmalemma of a muscle fiber, and the surrounding basal lamina. When needed, satellite cells are activated to form proliferative myoblasts, that …

Mar 30, 2010 · In this Perspective, we review the recent exciting findings that have established a key role for the ’longevity’ protein SirT1 in skeletal and heart muscle physiology and disease.

External lamina is a structure similar to basal lamina that surrounds the sarcolemma of muscle cells. It is secreted by myocytes and consists primarily of Collagen type IV , laminin and perlecan (heparan sulfate proteoglycan).

Oct 30, 2023 · Structure and cellular components of loose connective tissue. Lamina propria is an areolar connective tissue layer present in all mucous membranes found in the body.

Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice E Ganji, SN Lamia, M Stepanovich, N Whyte, RW Goulet, AC Abraham, ... Science Advances...