The MT-CO2 gene encodes for the second subunit of cytochrome c oxidase (complex IV), a component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. MT-CO2 is one of the three subunits which are responsible for the formation of the functional core of the cytochrome c oxidase .

Mar 30, 2025 · MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency, Nuclear Type 1 and Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes.

MT-CO2 gene: Along with the senescence of HMSCs, MT-CO2 gene methylation increased and its protein expression level significantly decreased. Treatment with 5-aza-2’-deoxycytidine inhibited COX2 methylation.

Jan 2, 2025 · Here, we show that glucose deprivation upregulates the expression of mitochondrial-cytochrome c oxidase II (MT-CO2), a subunit essential for the respiratory chain complex IV, in facilitating...

Dec 10, 2024 · Clinical resource with information about MT-CO2, MELAS syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Feb 9, 2025 · Title: Mitochondrial complex IV deficiency caused by a novel frameshift variant in MT-CO2 associated with myopathy and perturbed acylcarnitine profile.

Cytochrome c oxidase subunit II (COII or MTCO2) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation.

MT-CO2 is a prognostic marker in Kidney renal clear cell carcinoma, Pancreatic adenocarcinoma

(MT-ND5 = NADH dehydrogenase subunit 5) Results demonstrates that the presence of high levels of COX-2 is associated with poor prognosis for breast cancer patients and predicts bigger tumor size and lymph node metastasis.

Complete sequencing of the mitochondrial DNA genome in muscle identified a novel MT-CO2 variant, m.8163A>G predicting p. (Tyr193Cys). We present several lines of evidence, in proving the pathogenicity of this heteroplasmic mitochondrial DNA variant, as the cause of …