Cytochrome c oxidase subunit I (CO1 or MT-CO1) is one of three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of cytochrome c oxidase, also known as complex IV. Cytochrome c oxidase (EC 1.9.3.1) is a key enzyme in aerobic metabolism.

Mar 30, 2025 · MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I) is a Protein Coding gene. Diseases associated with MT-CO1 include Rare Mitochondrial Non-Syndromic Sensorineural Deafness and Mitochondrial Complex Iv Deficiency, Nuclear Type 1.

Feb 8, 2025 · Molecular characterization and haplotypes of hydatid cyst isolates collected from humans and ruminants in Setif Province (northeast of Algeria) based on mitochondrial cytochrome C oxidase subunit 1 (mt-CO1) gene sequences.

Jan 4, 2025 · Clinical resource with information about MT-CO1, Mitochondrial non-syndromic sensorineural hearing loss, MELAS syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

HGNC Approved Gene Symbol: MT-CO1. Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV.

Ubiquitous cytoplasmic expression with a granular pattern. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas. All transcripts of all genes have been analyzed regarding the location (s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

Molecular characterization and haplotypes of hydatid cyst isolates collected from humans and ruminants in Setif Province (northeast of Algeria) based on mitochondrial cytochrome C oxidase subunit 1 (mt-CO1) gene sequences.

Apr 1, 2015 · Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover.

Aug 28, 2023 · Encoded in the mitochondrial DNA, MT-CO1 catalyses the reduction of oxygen to water. COX1, a homologue of MT-CO1, has been related to longevity in the filamentous fungus Podospora anserina [207]. Mutations in the human MT-CO1 gene have been associated with several diseases, including neurodegenerative diseases [751].

This study aims to investigate the expression patterns of mitochondrially encoded cytochrome c oxidase 1 (MT-CO1) in different organs and tissues of MRL/lpr mice aged six and 18 weeks.