OCD patients who received active tDCS exhibited more rapid therapeutic safety learning (ps < .05) during the ERP challenge than patients who received sham tDCS. Conclusions: Frontopolar tDCS may modulate mPFC and DMN functional connectivity and …

Feb 11, 2019 · Using viral neuronal tracing in mice, we found that glutamatergic neurons from the basolateral amygdala (BLA Glu) project onto both medial prefrontal cortex glutamate (mPFC Glu) and GABA (mPFC GABA) neurons that locally innervate mPFC Glu neurons. Next, we developed an OCD checking mouse model with quinpirole-induced repetitive checking behaviors.

Recent evidence indicates that the efficacy of LPFC stimulation is augmented by sequential stimulation medial prefrontal cortex (MPFC) and orbitofrontal cortex (OFC) for subsets of patients with MDD and comorbid Obsessive Compulsive Disorder (OCD), and symptoms of negative ruminations and anxiety.

In an open-label mPFC rTMS trial with fMRI measures, Dunlop et al.90 demonstrated a significant reduction in OCD symptoms and found a significantly different fMRI pattern in the responder group, with increased mPFC connectivity with the bilateral somatosensory cortex and the left precuneus and decreased mPFC connectivity with the bilateral ...

Feb 2, 2019 · Using viral neuronal tracing in mice, we found that glutamatergic neurons from the basolateral amygdala (BLA Glu) project onto both medial prefrontal cortex glutamate (mPFC Glu) and GABA (mPFC GABA) neurons that locally innervate mPFC Glu neurons. Next, we developed an OCD checking mouse model with quinpirole-induced repetitive checking behaviors.

Oct 15, 2020 · Connectivity between the ventral capsule (VC) and medial prefrontal cortex (mPFC) is important to OCD symptomatology and may be normalized by VC/VS-DBS. Data in this figure reflect resting-state connectivity before stimulation.

Deep repetitive transcranial magnetic stimulation (dTMS) for OCD neuromodulates the bilateral anterior cingulate cortex (ACC) and dorsal medial prefrontal cortex (mPFC), which are known to be impaired in OCD.

HF DTMS over the mPFC-ACC alleviates OCD symptoms and may be used as a novel therapeutic intervention. Notwithstanding alternative explanations, this may stem from DTMS ability to directly modify ACC activity.

5 days ago · Obsessive-compulsive disorder (OCD) is a debilitating psychiatric illness that affects approximately 2% of the population [1, 2].Obsessions refer to intrusive thoughts or images that provoke distress and anxiety, while compulsions are repetitive actions or mental processes undertaken to alleviate such discomfort [].The primary treatments for OCD include cognitive behavioral therapy (CBT ...

Aug 31, 2021 · Exposed-based psychotherapy is a mainstay of treatment for obsessive-compulsive disorder (OCD) and anxious psychopathology. The medial prefrontal cortex (mPFC) and the default mode network (DMN), which is anchored by the mPFC, promote safety learning.