Sep 9, 2019 · In the present study, a basolateral amygdala (BLA)–prefrontal cortex (PFC)–periaqueductal gray (PAG)–spinal cord pathway was identified that is critical for the development of...

Jul 13, 2011 · In this study, we monitored changes in the magnitude of evoked field potentials (EFPs) in the mPFC–BLA and BLA–mPFC pathways following auditory fear conditioning and extinction, in freely moving rats.

Dec 18, 2013 · Retrieval of fear extinction memory is associated with increased firing of neurons in the medial prefrontal cortex (mPFC). It is unknown, however, how extinction learning-induced changes in mPFC activity are relayed to target structures in …

Two forebrain regions important in this associative learning are the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC). Recent work showed the BLA-mPFC pathway is activated when a cue reliably signals food, suggesting the BLA informs the mPFC of the cue’s value.

Feb 11, 2019 · These findings were verified in a mouse functional magnetic resonance imaging (fMRI) study, in which the BLA–mPFC functional connectivity was increased in OCD mice. Together, these findings define a unique BLA Glu →mPFC GABA→Glu circuit that controls the checking symptoms of OCD.

Sep 9, 2013 · Here we examine long-range connections between the mouse mPFC and BLA, using whole-cell recordings, optogenetics, and two-photon microscopy. We first identify two non-overlapping populations of layer 2 pyramidal neurons that directly project to either the BLA or contralateral mPFC.

Dec 16, 2021 · The control of dysregulated medial prefrontal cortex (mPFC) over the basolateral amygdala (BLA) is related to depression. However, the oscillation interaction in the mPFC-BLA circuit has remained elusive.

Aug 10, 2024 · As traditional Pavlovian fear conditioning models fall short in encapsulating the breadth of natural escape behaviors, we introduce a novel dataset to bridge this gap, capturing the defensive...

Here, we review this rich body of literature, aligning major events in mPFC development with the maturation of complex behaviors. We focus on emotional memory and cognitive flexibility, and highlight new work linking mPFC circuit disruption to alterations of …

Sep 5, 2023 · Within the network, mPFC led BLA in θ low and β high bands, whereas BLA led mPFC in θ high band. Unlike theta rhythms, β high emerging during safe-zone-oriented escaping behaviors presented several properties implicating its relevance to top–down processing.