May 6, 2020 · Our findings thus reveal a target cell-based dysregulation of mPFC-to-amygdala transmission for stress-induced anxiety. In the brain, the medial prefrontal cortex (mPFC) and amygdala are...

5 days ago · Upon acute stressor onset, mPFC catecholamine and glutamate levels rise rapidly [16,17,18], and continued excitation of mPFC pyramidal neurons is facilitated by stress-induced increases in ...

We review literature that indicates that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the mPFC, as well as shaping how the mPFC acts within a network of brain structures to modulate responses to stress.

Nov 12, 2024 · Here, we show that spatially-restricted complement activation mediates stress-induced heterogeneous microglia activation and synapse loss localized to the upper layers of the medial...

The medial prefrontal cortex (mPFC), a hub region involved in emotional processing and stress response elaboration, is highly impacted in MDD patients and animal models of chronic stress. Recent advances showed alterations in the morphology and activity of mPFC neurons along with profound changes in their transcriptional programs.

May 18, 2023 · Our findings indicate that chronic stress exposure preferentially modulates the activity of the mPFC-BLA circuit in a subregion (dmPFC) and laminar (layer V) -dependent manner.

Nov 1, 2019 · In this review, we discuss the interplay among stress, the mPFC, and interneurons in both humans and rodents to outline a prominent role for interneurons in stress-induced prefrontal adaptation.

Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala–mPFC connectivity emerge.

Jan 1, 2021 · These results highlight the sensitivity of mPFC neurons to stress and the associated neurobiological changes, which in the case of chronic stress reflects reduced excitatory neuron output and disrupted mPFC-dependent behavioral function.

Mar 13, 2024 · One of the key downstream targets of the mPFC, the lateral habenula (LHb), is essential for chronic stress (CS)-induced depressive and anxiety-like behaviors.