Sep 1, 2019 · The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability.

This brain region is involved in a wide range of higher-order cognitive functions, including speech formation (Broca's area), gaze (frontal eye fields), working memory (dorsolateral prefrontal cortex), and risk processing (e.g. ventromedial prefrontal cortex).

Some investigators divide the PFC into two broad regions mainly related to their functions: the dlPFC and the ventromedial PFC, which is also referred to as the orbitofrontal PFC.

Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time-scales ranging from seconds to days. How can all these roles be reconciled?

Mar 18, 2019 · Our mapping revealed highly overlapping long-range input patterns for the four functionally distinct mPFC cell types, with quantitative differences in key brain regions. Extensive connectivity...

Sep 30, 2024 · The MPFC can be broadly divided into three main regions: 1. The dorsal MPFC: This is the upper part, involved in cognitive tasks and self-referential thinking. 2. The ventral MPFC: Located in the lower portion, this area is crucial for …

The medial prefrontal cortex (mPFC), a prominent brain region located within the frontal lobe, is primarily responsible for functions that include decision-making processes and judgement (Bechara, Damasio, & Damasio, 2000); attentional processing (Miller & Buschman, 2013), learning and memory consolidation (Euston, Gruber, & McNaughton, 2012 ...

Mar 16, 2022 · Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the...

Aug 2, 2019 · The mPFC consists of four distinct neuroanatomical subregions along the dorsal to ventral axis: medial precentral area (PrCm), anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL).

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability.