May 6, 2020 · Our findings thus reveal a target cell-based dysregulation of mPFC-to-amygdala transmission for stress-induced anxiety. In the brain, the medial prefrontal cortex (mPFC) and amygdala are...

A wealth of data has implicated the medial prefrontal cortex (mPFC) in the regulation of anxiety. Norepinephrine (NE) is a crucial neuromodulator of arousal and vigilance believed to be responsible for many of the symptoms of anxiety disorders.

Feb 21, 2020 · Recently developed optogenetic and chemogenetic tools that allow high-fidelity control of neuronal activity in preclinical models have begun to elucidate the contributions of the PFC and its...

The anxiogenic effect of the BLA-mPFC pathway was exacerbated by the viral deletion of cannabinoid receptor CB1 in the mPFC-projecting BLA neurons, suggesting the role of endocannabinoid negative feedback in anxiety regulation in the BLA-mPFC circuit.

Mar 13, 2024 · Through circuit-specific in vivo fiber photometry, we found that Ca 2+ activity in dorsal mPFC (dmPFC) axon terminals within the LHb was increased during exposure to stressful and...

Mar 12, 2014 · Decreased medial prefrontal cortex (mPFC) neuronal activity is associated with social defeat-induced depression- and anxiety-like behaviors in mice. However, the molecular mechanisms underlying the decreased mPFC activity and its prodepressant role remain unknown.

May 3, 2016 · Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects.

Aug 29, 2019 · Exogenous oxytocin application to the mPFC can attenuate anxiety-related behavior . It may engage GABAergic neurons to modulate downstream brain regions associated with anxiety . The altered connectivity between the mPFC, vHipp, or BLA contributes to the changes in anxiety status.

Jan 1, 2021 · In anxiety blocks, oscillatory mPFC theta activity was found to decrease in the action encoding period, and synchrony between the mPFC and the ventral tegmental area (VTA), the dopamine containing region implicated in reward processing, was …

Feb 21, 2025 · Various neuromodulatory interventions targeting the mPFC, including repetitive transcranial magnetic stimulation and theta-burst stimulation, have demonstrated efficacy in modifying mPFC activity and ameliorating anxiety symptoms.