IVISense MMP 680 per mouse. • When stored correctly at 2-8 ºC and protected from light, IVISense MMP 680 is stable for up to 6 months. Animal injection and imaging • Take a time-zero image of each subject before injection of the agent. • With fluorescent models, a naïve control …
IVISense MMP Fluorescent Probes - Revvity
IVISense™ MMP and IVISense MMP FAST fluorescent probes (formerly MMPSense) are matrix metalloproteinase (MMP) activatable probes that are optically silent upon injection and produce fluorescent signals after cleavage …
Inject 100 μl of IVISense MMP 750 FAST intravenously into the mouse. The optimal imaging time point is 12-24 hours post injection of the agent. It is recommended to do an initial time course …
- Studies of Mmpsense in vivo Mouse
The recommended procedure for in vivo imaging with IVISense™ MMP Õ × Ï Fluorescent Probe is administration via tail vein injection and imaging 24 hours post injection. Imaging in …
Analysis of the trajectory of osteoarthritis development in a mouse ...
MMP activity was then evaluated in vivo serially in a mouse model of chronic, injury-induced OA. To track MMP activity over time, mice were imaged 1-8 weeks after OA-inducing surgery. …
- Author: Averi A. Leahy, Shadi A. Esfahani, Andrea T. Foote, Carrie K. Hui, Roshni S. Rainbow, Daisy S. Nakam...
- Publish Year: 2015
Detection of MMP-2 and MMP-9 activity in vivo with a triple …
We report a novel activatable NIR fluorescent probe for in vivo detection of cancer-related matrix metalloproteinase (MMP) activity. The probe is based on a triple-helical peptide substrate …
Analysis of the Trajectory of Osteoarthritis …
Nov 10, 2014 · In vitro studies confirmed that NIR fluorescence imaging identified enhanced MMP activity in IL‐1β–treated human chondrocytes. In vivo imaging showed significantly higher fluorescence intensity in OA knees compared to …
DESCRIPTION: MMPSenseTM 680 is a protease activatable fluorescent in vivo imaging agent that is activated by key matrix metalloproteinases (MMPs) including MMP-2, -3, -9 and -13. …
Non-invasive dual fluorescence in vivo imaging for detection of ...
May 1, 2016 · Based on characteristics of arthritis, we exploited αCD11b antibody conjugated with APC and 750F, as in vivo fluorescence imaging agents, to detect infiltrated leukocytes and …
Real-Time Video Imaging of Protease Expression In Vivo
Jan 12, 2011 · We synthesized a series of PEGylated molecular beacons, screened their activity in vitro and in vivo, and assessed their suitability for video imaging of protease expression in an MMP-overexpressing tumor-bearing …
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