Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [5]

Matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinase (MMP) family, which can degrade multiple ECM components. MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions. In this review, we summarized the function of MMP-3 and discussed its effects on biological activities.

Mar 30, 2025 · MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include Coronary Heart Disease 6 and Conjunctivochalasis. Among its related pathways are GPCR downstream signalling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity.

Apr 7, 2025 · Gene target information for MMP3 - matrix metallopeptidase 3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes.

Jan 24, 2022 · Matrix metalloproteinases (MMPs) may have a role in the lung damage and regeneration that occur in severe patients. We studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in...

A potential mechanism of MMP3 in regulating tumor cell proliferation and invasion was mediated via Erk1/2 an NF-κB signaling. This study reveals that MMP3 is a promising target and the combined treatment with oncolytic virus is a potential strategy for cancer therapy.

MMP3 is expressed by epithelial cells just beyond the leading edge of the wound where the basement membrane remains intact, implicating its role in epithelial cell migration (Martins et al., 2013). MMP3 deficiency delays healing, wound contraction, and wound closure, demonstrating its importance in normal healing (Krishnaswamy et al., 2017).

Jan 1, 2022 · Background: Matrix metalloproteinase 3 (MMP3) is known as an inflammatory factor; however, the effectiveness of MMP3 for diagnosis of pneumonia and predicting …

Matrix metalloproteinase-3 or MMP3 also known as stromelysin-1 is an enzyme that is actively involved in joint destruction in rheumatoid arthritis (RA) patients. Screening the last three decades, it appears that serum levels of MMP3 reflect positively RA disease activity, joint and bone injury, and …