Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene. [1][2][3][4] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [2]

Mar 30, 2025 · MMP1 (Matrix Metallopeptidase 1) is a Protein Coding gene. Diseases associated with MMP1 include Recessive Dystrophic Epidermolysis Bullosa and Pulmonary Disease, Chronic Obstructive. Among its related pathways are Matrix metalloproteinases and Cytokine Signaling in Immune system.

Feb 8, 2025 · Gene target information for MMP1 - matrix metallopeptidase 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Matrix metalloprotease-1 (MMP1) has been implicated in many human disease processes, however the lack of a well characterized murine homologue has significantly limited the study of MMP1 and the development of MMP-targeted therapeutics.

Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a protein and cloned as a cDNA, and is considered the prototype for all the interstitial collagenases.

Nov 9, 2021 · In this study, we demonstrated that MMP1 derived from TAMs markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associated with tumor invasion and metastasis.

Sep 3, 2024 · MMP-1, also known as human fibroblast collagenase, was the first vertebrate collagenase to be purified and cloned, making it the prototype for interstitial collagenases. It is synthesized as an inactive zymogen that becomes active through proteolytic removal of N-terminal residues.

Matrix metalloprotease-1 (MMP1), a collagenase and activator of the G protein-coupled protease activated receptor-1 (PAR1), is an emerging new target implicated in oncogenesis and metastasis in diverse cancers.

Feb 1, 2005 · Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a protein and cloned as a cDNA, and is considered the prototype for all the interstitial collagenases.