Mar 30, 2025 · MLXIPL (MLX Interacting Protein Like) is a Protein Coding gene. Diseases associated with MLXIPL include Williams-Beuren Syndrome and Opitz-Kaveggia Syndrome. Among its related pathways are Integration of energy metabolism and Angiopoietin-like protein 8 regulatory pathway.

Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. [5] [6] The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.

Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity).

Feb 8, 2025 · Gene ID: 51085, updated on 8-Feb-2025. This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes.

MLXIPL (bHLHd14, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH) protein expression summary.

Mar 19, 2020 · Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic processes. We show that MLX and glucose-sensing family members MLXIP/MondoA and MLXIPL/ChREBP bind LDs via C …

Feb 21, 2023 · MLX interacting protein like (MLXIPL) is an important regulator of glucolipid metabolism and is involved in tumor progression. We aimed to clarify the role of MLXIPL in HCC and its underlying mechanisms.

Sep 18, 2024 · Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

Synonym (s): CHREBP, MIO, MONDOB, WS-bHLH, bHLHd14, carbohydrate response element binding protein. Previous symbol (s) and name (s): MLX interacting protein-like, WBSCR14, Williams Beuren syndrome chromosome region 14. Type: gene with protein product. Chromosomal location: 7q11.23. OMIM: 605678. HGNC: …

May 8, 2012 · HGNC Approved Gene Symbol: MLXIPL. Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38) : 7:73,593,202-73,647,907 (from NCBI) Meng et al. (1998) constructed a physical map encompassing the 1.5-Mb region that is commonly deleted in Williams-Beuren syndrome (WBS; 194050).