MERTK - Wikipedia
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. [5][6][7] This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase …
Mertk: An emerging target in cancer biology and immuno-oncology
Mertk, a type I Receptor Tyrosine Kinase (RTK) and member of the TAM (Tyro3, Axl, and Mertk) family of homologous tyrosine kinases, has important roles in signal transduction both …
MERTK Gene - GeneCards | MERTK Protein | MERTK Antibody
Mar 30, 2025 · MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Retinitis Pigmentosa. …
Focus on Molecules: MERTK - PMC
MERTK (UniProt accession Q12866) is a single pass transmembrane receptor that belongs to the TAM (T yro3, A xl and M ertk) family of receptor tyrosine kinases. MERTK is highly expressed …
MerTK is a mediator of alpha-synuclein fibril uptake by human
Feb 1, 2024 · Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory, homeostatic phagocytosis of diverse types of cellular debris. Highly expressed …
MERTK in Cancer Therapy: Targeting the Receptor Tyrosine Kinase …
In this review we discuss MERTK inhibition as an emerging strategy for cancer therapy, focusing on MERTK expression and function in neoplasia and its role in mediating resistance to …
MerTK + macrophages promote melanoma progression and
Oct 4, 2024 · Here, our single-cell RNA sequencing data identify a subpopulation of macrophages expressing high levels of the phagocytic receptor MER proto-oncogene tyrosine kinase …
Targeting MERTK on tumour cells and macrophages: a potential
Aug 23, 2024 · We show that MERTK and AXL contribute to increased proliferation and survival of meningioma and schwannoma cells, which we inhibited in vitro using the MERTK/FLT3 …
Mertk: An emerging target in cancer biology and immuno-oncology
Mertk, a type I Receptor Tyrosine Kinase (RTK) and member of the TAM (Tyro3, Axl, and Mertk) family of homologous tyrosine kinases, has important roles in signal transduction both …
MerTK signaling in macrophages promotes the synthesis of …
We now show that activation of MerTK in human macrophages led to ERK-mediated expression of the gene encoding sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2), …