MATRix is a combination of cancer drugs. It is used to treat primary CNS lymphoma. It may sometimes be used to treat other cancers. It may also be used to harvest stem cells in people having a stem cell transplant.

MATRIX (Methotrexate, Cytarabine, Thiotepa and Rituximab) Version 2 Review date: May 2020 Page 2 of 5 Full dose methotrexate should only be given in the presence of a normal serum creatinine and CrCl ≥ 80mL/min.

The MATRix (methotrexate, cytarabine, thiotepa, rituximab) regimen has significantly improved outcomes of patients with primary central nervous system lymphoma (PCNSL). The original trial population, however, was young and fit with few comorbidities.

Out of 156 patients treated with MATRix, 79% (n=123, 95% CI 71-85) achieved a response (35% complete response, 44% partial response), 4% (n=6) had stable disease and 10% (n=16) had documented progressive disease.

Apr 7, 2016 · The MATRix regimen (methotrexate, cytarabine, thiotepa, rituximab) may be the new standard chemoimmunotherapy for the treatment of patients aged up to 70 years with newly diagnosed primary...

Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 …

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Initiate at a rate of 20% of the total dose for the first 30 minutes and then 80% of the dose for the next 60 minutes (total infusion time of 90 minutes). If the more rapid infusion is tolerated, this infusion schedule can be used when administering subsequent infusions.

When MATRix regimen is used for priming and harvesting: 1. Liaise with BMT nurse co-ordinator for timing of harvest and possible transplant slot. 2. Stem cell collection should be performed on days 13, 14 & 15 of the cycle. 3. Aim to collect 4.0x106 CD34-positive cells/kg [minimum of 2.0x106 CD34-positive cells/kg]. 4.

Nov 24, 2017 · MATRix (methotrexate, cytarabine, thiotepa, rituximab) This treatment cycle is repeated every 21 days. You will have up to 4 cycles. Once you have finished your chemotherapy, you may be given radiation therapy; your doctor will advise you if this is necessary. Day: Treatment: How it is given: How long it takes-5 and 0: Rituximab (ri-TUX-i-mab)